600-401-EK5
SIK2 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-EK5
- Zusätzliche Namen:
- SIK2|SIK2 Antibody, QIK, SNF1LK2, LOH11CR1I, KIAA0781, QIK, Qin-induced kinase, SIK-2
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-SIK2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide near the internal region of human SIK2.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9H0K1
- Synonyme:
- LOH11CR1I;QIK;qin-induced kinase;Salt-inducible kinase 2;salt-inducible protein kinase 2;salt-inducible serine/threonine kinase 2;serine/threonine-protein kinase SIK2;serine/threonine-protein kinase SNF1-like kinase 2;SIK-2;SNF1-like kinase 2;SNF1LK2
- Weitere Details:
- Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
- Versandbedingungen:
- Dry Ice