600-401-EC6
RTP801 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-EC6
- Zusätzliche Namen:
- DDIT4|RTP801 Antibody, Dig2, REDD1, REDD-1, RTP801, DNA damage-inducible transcript 4 protein, HIF-1 responsive protein RTP801
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-RTP801 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 12 amino acid synthetic peptide from near the internal region of human RTP801.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9NX09
- Synonyme:
- Dig2;DNA damage-inducible transcript 4 protein;HIF-1 responsive protein RTP801;protein regulated in development and DNA damage response 1;REDD-1;REDD1
- Weitere Details:
- RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
- Versandbedingungen:
- Dry Ice