600-401-DS3
PPM1D Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-DS3
- Zusätzliche Namen:
- PPM1D|Protein phosphatase Mg2+/Mn2+ dependent 1D, p53-induced protein phosphatase 1, PP2C-DELTA, Protein phosphatase 1D, WIP1
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-PPM1D antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid peptide near the C-terminus of human PPM1D.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q8IVR6
- Synonyme:
- IDDGIP;JDVS;p53-induced protein phosphatase 1;PP2C-DELTA;protein phosphatase 1D;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium-dependent 1 delta;protein phosphatase Wip1;wild-type p53-induced phosphatase 1;WIP1
- Weitere Details:
- Wild-type p53 induced phosphatase 1 (WIP1) / protein phosphatase magnesium-dependent 1 delta (PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP2C family of serine/threonine protein phosphatases which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53 (1,2). Studies have shown that it is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways (2,3). PPM1D deletion results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development (4,5).
- Versandbedingungen:
- Dry Ice