600-401-DR0
PNAS4 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-DR0
- Zusätzliche Namen:
- DESI2|PNAS4 Antibody, DESI, DESI1, DeSI-2, PNAS-4, PPPDE1, CGI-146, FAM152A, C1orf121, Desumoylating isopeptidase 2, PPPDE peptidase domain-containing protein 1
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-PNAS4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the C-terminus of human PNAS4.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q9BSY9
- Synonyme:
- C1orf121;CGI-146;DESI;DeSI-2;DESI1;desumoylating isopeptidase 1;Desumoylating isopeptidase 2;deubiquitinase DESI2;FAM152A;family with sequence similarity 152, member A;PNAS-4;PPPDE peptidase domain-containing protein 1;PPPDE1;Protein FAM152A
- Weitere Details:
- PNAS4 is a highly conserved protein that shares high homology from plants to animals. It was initially identified as a putative apoptosis-related protein in the human acute promyelocytic leukemia cell line NB4. PNAS4 is activated during the early response to DNA damage and can inhibit proliferation via apoptosis when overexpressed in some tumor cells such as U2OS, SKOV3, and A549. PNAS4 inhibits tumor cell proliferation through the following mechanisms: (i) overexpression of PNAS4 causes S phase arrest by regulating the expression of cell cycle-related proteins and (ii) PNAS4 induces apoptosis through the mitochondrial apoptosis pathway. Recent evidence has shown that PNAS4 may be involved in the genesis of some cancers and could be a potential candidate for lung cancer therapy alone or in combination with gemcitabine. At least two isoforms of PNAS4 are known to exist.
- Versandbedingungen:
- Dry Ice