600-401-DL8
PHAP I Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-DL8
- Zusätzliche Namen:
- ANP32A|PHAP I Antibody, LANP, MAPM, PP32, HPPCn, PHAP1, PHAPI, I1PP2A, C15orf1, LANP, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-PHAP I antibody was raised with a synthetic peptide corresponding to amino acids at C-terminus of human PHAP I.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- P39687
- Synonyme:
- acidic (leucine-rich) nuclear phosphoprotein 32 family, member A;acidic leucine-rich nuclear phosphoprotein 32 family member A;acidic nuclear phosphoprotein pp32;C15orf1;cerebellar leucine rich acidic nuclear protein;epididymis secretory sperm binding protein;hepatopoietin Cn;HPPCn;I1PP2A;inhibitor-1 of protein phosphatase-2A;LANP;leucine-rich acidic nuclear protein;MAPM;mapmodulin;PHAP1;PHAPI;potent heat-stable protein phosphatase 2A inhibitor I1PP2A;PP32;putative HLA-DR-associated protein I;putative human HLA class II associated protein I
- Weitere Details:
- Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
- Versandbedingungen:
- Blue Ice