600-401-DH9
P2RX7 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-DH9
- Zusätzliche Namen:
- P2RX7|P2X purinoceptor 7, P2X7, purinergic receptor P2X ligand-gated ion channel 7
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-P2RX7 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid peptide near the C-terminus of human P2RX7.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q99572
- Synonyme:
- ATP receptor;P2X purinoceptor 7;P2X7;P2X7 receptor;P2Z receptor;Purinergic receptor;purinergic receptor P2X, ligand gated ion channel, 7;purinergic receptor P2X7 variant A;purnergic receptor P2X 7
- Weitere Details:
- The purinergic receptor P2X ligand-gated ion channel 7 (P2RX7) belongs to the family of purinoceptors for ATP (1). This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules (1,2). Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression (2). Recent studies have suggested that P2RX7 may play a key role in immune-mediated diseases such as rheumatoid arthritis (3) as well as neuropsychiatric disorders (4).
- Versandbedingungen:
- Dry Ice