600-401-DH7
OTUD5 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-DH7
- Zusätzliche Namen:
- OTUD5|OTUD5 Antibody, DUBA, OTU domain-containing protein 5, Deubiquitinating enzyme A, DUBA
- Anwendung:
- ELISA, IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-OTUD5 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide near the C-terminus of the human OTUD5.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q96G74
- Synonyme:
- deubiquinating enzyme A;deubiquitinating enzyme A;DUBA;MCAND;OTU domain containing 5;OTU domain-containing protein 5
- Weitere Details:
- OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.
- Versandbedingungen:
- Dry Ice