600-401-DC9
NOD3 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-DC9
- Zusätzliche Namen:
- NLRC3|NOD3 Antibody, NOD3, CLR16.2, NOD3, Protein NLRC3, CARD15-like protein
- Anwendung:
- ELISA, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-NOD3 antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the internal region of human NOD3.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q7RTR2
- Synonyme:
- CARD15-like protein;caterpiller protein 16.2;CLR16.2;NACHT, LRR and CARD domains-containing protein 3;NLR family CARD domain-containing protein 3;NOD-like receptor C3;NOD3;Nucleotide-binding oligomerization domain protein 3;nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3
- Weitere Details:
- NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
- Versandbedingungen:
- Blue Ice