600-401-CV0
MMS21 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-CV0
- Zusätzliche Namen:
- MMS21 Antibody, NSE2, MMS21, ZMIZ7, C8orf36, E3 SUMO-protein ligase NSE2, MMS21 homolog, hMMS21|NSMCE2
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-MMS21 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the C-terminus of human MMS21.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q96MF7
- Synonyme:
- C8orf36;E3 SUMO-protein ligase NSE2;E3 SUMO-protein transferase NSE2;methyl methanesulfonate sensitivity gene 21;MMS21;MMS21 homolog;non-SMC element 2, MMS21 homolog;non-structural maintenance of chromosomes element 2 homolog;NSE2;NSMCE2/PVT1 fusion;PVT1/NSMCE2 fusion;zinc finger, MIZ-type containing 7;ZMIZ7
- Weitere Details:
- MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesion components RAD21 and STAG2.
- Versandbedingungen:
- Dry Ice