600-401-CU5
Mimitin Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-CU5
- Zusätzliche Namen:
- Mimitin Antibody, MMTN, B17.2L, mimitin, NDUFA12L, Mimitin, mitochondrial, Myc-induced mitochondrial protein, MMTN|NDUFAF2
- Anwendung:
- ELISA, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-Mimitin antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the C-terminus of human Mimitin.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q8N183
- Synonyme:
- B17.2-like;B17.2L;MC1DN10;mimitin;mimitin, mitochondrial;MMTN;Myc-induced mitochondrial protein;NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2;NADH dehydrogenase (ubiquinone) complex I, assembly factor 2;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2;NADH dehydrogenase 1 alpha subcomplex assembly factor 2;NDUFA12-like protein;NDUFA12L
- Weitere Details:
- Mimitin, a small mitochondrial protein, whose transcription is directly stimulated by c-Myc, is highly expressed in 80% of esophageal squamous cell carcinomas (ESCC). Suppression of Mimitin expression by RNA interference had no effect in cancerous cell lines such as human cervical carcinoma or hepatocarcinoma cell lines, but caused a decrease in cell proliferation in human glioblastoma, embryonic lung fibroblastic cells, and ESCC, suggesting Mimitin may play a special role in these types of cells. Mimitin expression is also regulated by MAPK kinases and IL-1, but not through the NF-kB-related pathway. It will interact with the microtubular protein MAP1S and can affect the activities of caspase-3 and -7 in cells stimulated to develop apoptosis. Other experiments suggest that Mimitin also acts as a molecular chaperone for the assembly of the mitochondrial complex I.
- Versandbedingungen:
- Dry Ice