600-401-CQ9
MARCH8 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-CQ9
- Zusätzliche Namen:
- MARCH8|MARCH8 Antibody, MIR, c-MIR, RNF178, MARCH-VIII, MIR, E3 ubiquitin-protein ligase MARCH8, Cellular modulator of immune recognition
- Anwendung:
- ELISA, IHC, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-MARCH8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 17 amino acid synthetic peptide from near the C-terminus of human MARCH8.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q5T0T0
- Synonyme:
- c-MIR;c-mir, cellular modulator of immune recognition;Cellular modulator of immune recognition;cellular modulator of immune recognition (c-MIR);CMIR;E3 ubiquitin-protein ligase MARCH8;E3 ubiquitin-protein ligase MARCHF8;MARCH-VIII;MARCH8;membrane associated ring finger 8;membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase;membrane-associated RING finger protein 8;membrane-associated RING-CH protein VIII;MIR;RING finger protein 178;RING-type E3 ubiquitin transferase MARCH8;RING-type E3 ubiquitin transferase MARCHF8;RNF178
- Weitere Details:
- MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.
- Versandbedingungen:
- Dry Ice