600-401-CQ3
MAP1 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-CQ3
- Zusätzliche Namen:
- MAP1 Antibody, MAP-1, PNMA4, Modulator of apoptosis 1, Paraneoplastic antigen Ma4, MAP-1|MOAP1
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-MAP-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human MAP-1.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q96BY2
- Synonyme:
- MAP-1;MAP1;modulator of apoptosis 1;paraneoplastic antigen like 4;paraneoplastic antigen Ma4;paraneoplastic Ma antigen family member 4;PNMA4
- Weitere Details:
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
- Versandbedingungen:
- Dry Ice