GOLPH3 Antibody

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SKU:: 600-401-BM4
Zusätzliche Namen:: GOLPH3|GOLPH3 Antibody, GOPP1, GPP34, MIDAS, Golgi phosphoprotein 3, Coat protein GPP34
Anwendung:: ELISA, WB, IF
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-GOLPH3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide from near the N-terminus of human GOLPH3.
Formulierung:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q9H4A6
Synonyme:: coat protein GPP34;coat-protein;golgi peripheral membrane protein 1, 34 kDa;Golgi phosphoprotein 3;golgi protein;golgi-associated protein;GOPP1;GPP34;MIDAS;mitochondrial DNA absence factor;Vps74
Weitere Details:: GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin. GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway. Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro. Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF. Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes. These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.

Versandbedingungen:: Dry Ice