600-401-BH5
FRMPD2 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 600-401-BH5
- Zusätzliche Namen:
- FRMPD2|FRMPD2 Antibody, PDZK4, PDZD5C, PDZK5C, PDZK4, FERM and PDZ domain-containing protein 2, PDZ domain-containing protein 4
- Anwendung:
- ELISA, IHC, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
- Immunogen:
- Anti-FRMPD2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the N-terminus of human FRMPD2.
- Formulierung:
- 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Uniprot:
- Q68DX3
- Synonyme:
- FERM and PDZ domain-containing protein 2;PDZ domain containing 5C;PDZ domain-containing protein 4;PDZ domain-containing protein 5C;PDZD5C;PDZK4;PDZK5C
- Weitere Details:
- The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
- Versandbedingungen:
- Blue Ice