CDCA8 Antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 600-401-AJ4
Zusätzliche Namen:: CDCA8|CDCA8 Antibody, BOR, DasraB, MESRGP, BOREALIN, PESCRG3, Borealin, Cell division cycle-associated protein 8, hDasra-B
Anwendung:: ELISA, WB, IF
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride
Immunogen:: Anti-CDCA8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 19 amino acid synthetic peptide near the N-terminus of the human CDCA8.
Formulierung:: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Uniprot:: Q53HL2
Synonyme:: BOR;borealin;cell division cycle-associated protein 8;Dasra B;dasra-B;DasraB;hDasra-B;MESRGP;pluripotent embryonic stem cell-related gene 3 protein
Weitere Details:: CDCA8 is a component of a chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The chromosomal passenger complex, which includes Survivin, CDCA8, INCENP and Aurora-B, is known to play crucial roles during mitosis and cell division. It was found that CDCA8 interacting with Aurora-B, INCENP and Survivin, increases during G2/M phase and then reduces after exit from M phase. CDCA8 is cell cycle regulated, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis and abnormal tissue development, indicating its critical role for cell proliferation. Recent studies show that CDCA8 is essential for cell proliferation during early embryonic development, and its early embryonic lethality cannot be rescued by the loss of p53. Its aberrant expression is linked to a poor prognosis for gastric cancer.

Versandbedingungen:: Dry Ice