200-401-946
AGAP2 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 200-401-946
- Zusätzliche Namen:
- AGAP2|rabbit anti-AGAP2 antibody, AGAP-2, AGAP 2, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 antibody, ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 antibody, centaurin gamma1 antibody, Centg1 antibody
- Anwendung:
- ELISA, WB
- Konzentration:
- 2 mg/ml
- Physischer Zustand:
- Lyophilized
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C liquid. Aliquot. Avoid freeze/thaw cycles., -20[o]C/-70[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1-836 of human AGAP2 protein.
- Formulierung:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q99490
- Synonyme:
- Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2;arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2;Centaurin-gamma-1;centaurin, gamma 1;CENTG1;GGAP2;GTP-binding and GTPase activating protein 2;GTP-binding and GTPase-activating protein 2;phosphatidylinositol 3-kinase enhancer;phosphoinositide 3-kinase enhancer;PIKE
- Weitere Details:
- This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI). AGAP2 (also known as Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2) is a GTPase activating protein that inactivates Arf. The expression of AGAP2 is amplified in human glioblastoma cells. GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. Anti-AGAP2 Antibody is useful for researchers interested in Developmental Biology, apoptosis, Cancer, Immunology, and Nuclear Signaling research.
- Versandbedingungen:
- Ambient