200-401-932
RFFL Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 200-401-932
- Zusätzliche Namen:
- rabbit anti-RFFL antibody, Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like|RFFL
- Anwendung:
- ELISA, IHC, WB
- Konzentration:
- 5 mg/ml
- Physischer Zustand:
- Lyophilized
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C liquid. Aliquot. Avoid freeze/thaw cycles., -20[o]C/-70[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a recombinant protein corresponding to amino acids 1-363 of human RFFL protein.
- Formulierung:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Uniprot:
- Q8WZ73
- Synonyme:
- CARP-2;CARP2;caspase 8 and 10 associated RING protein-2;caspase regulator CARP2;caspases-8 and -10-associated RING finger protein 2;E3 ubiquitin-protein ligase rififylin;FRING;FYVE-RING finger protein SAKURA;RIFIFYLIN;ring finger and FYVE-like domain containing 1;RING finger and FYVE-like domain-containing protein 1;RING finger protein 189;RING finger protein 34-like;RING-type E3 ubiquitin transferase rififylin;RNF189;RNF34L
- Weitere Details:
- This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI). RFFL, also known as Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kB activation. RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein. Anti-RFFL Antibody is useful for researcher interested in Cancer, Immunology, transcription, and TNF-alpha/NF-kB research.
- Versandbedingungen:
- Ambient