200-301-MV2S

ModDetect[TM] Phosphorothioate Clone PS08

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 200-301-MV2S
Zusätzliche Namen:: Phosphorothioate, PS, ASO, anti-sense oligonucleotide, siRNA, RNA therapeutic
Anwendung:: ELISA
Konzentration:: 0.992 mg/ml
Physischer Zustand:: Liquid
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Mouse
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: ModDetect™ Phosphorothioate Clone PS08 was prepared from cell culture supernatant produced by repeated immunizations with a proprietary oligo sequence.
Formulierung:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Klon:: PS08
Weitere Details:: Not For Commercial Use. Current studies focusing on RNA therapeutics use as potential drugs antisense oligonucleotides (ASO), short interfering RNA (siRNA), and micro RNA (miRNA). The choice of oligonucleotide chosen for a specific treatment is dependent on many factors. However, all oligo therapeutics must be modified in some manner, as unmodified nucleotides are difficult to identify and are highly susceptible to degradation by endogenous nucleases. Modifications can be created within the sugar-phosphate backbone (first generation), the ribose sugar (second and third generation), or at multiple locations (third generation). Antibodies to modified oligonucleotides are useful for basic immunoassays including, ELISA, IHC, and IF. In addition, several types of toxicology assays (immunogenicity assays), such as antibody-drug assays (ADA) or other pharmacokinetic (PK) and pharmacodynamic (PD) studies require oligonucleotide antibodies as analytical tools for general research and preclinical trial experiments. Antibodies to an oligonucleotide therapeutic allow researchers to assess cellular uptake, tissue distribution, and can serve as a positive control for immunogenicity studies.

Versandbedingungen:: Dry Ice