PSD95 Antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 200-301-G33
Zusätzliche Namen:: Dlg4|DLG4, SAP90, Synapse-associated protein 90, Postsynaptic density protein 95, Disks large homolog 4
Anwendung:: IHC, WB, IF
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Rat
Lagerbedingungen:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Mouse
Reaktivitäten:: Bovine, Mouse, Rat
Immunogen:: PSD95 Antibody was produced in mice by repeated immunizations raised against recombinant rat PSD-95.
Klon:: 7E3
Uniprot:: P31016
Synonyme:: discs large homolog 4;discs, large homolog 4;disks large homolog 4;Dlgh;Dlgh4;postsynaptic density protein 95;PSD;PSD-;PSD-95;PSD-95 alpha 2b;PSD-95 beta;PSD95;SA;SAP-90;SAP90;SAP90A;synapse-associated protein 90;synapse-associated protein SAP90
Weitere Details:: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex. These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins. Thus different PDZ domains of PSD-95 might be specialized for distinct functions. PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning. Mutations in PSD95 are associated with autism.

Versandbedingungen:: Dry Ice