200-301-E84
Alpha A Crystallin Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 200-301-E84
- Zusätzliche Namen:
- CRYAA|Heat shock protein beta4, Acry 1, CRYA1, CRYAA, HspB4, Alpha-crystallin A chain
- Anwendung:
- ELISA, WB, IF
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Mouse
- Reaktivitäten:
- Bovine, Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Alpha Crystallin Antibody was produced in mice by repeated immunizations with Native Alpha Crystallin protein.
- Formulierung:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Klon:
- 1H3.B8
- Uniprot:
- P02489
- Synonyme:
- alpha-crystallin A chain;alpha-crystallin A2 chain;CRYA1;CRYAA;CRYAA2;crystallin, alpha-1;CTRCT9;heat shock protein beta-4;HSPB4;human alphaA-crystallin (CRYA1)
- Weitere Details:
- The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with Hsp25 and Hsp27. Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance. In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA. Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases.
- Versandbedingungen:
- Dry Ice