200-301-E29
Rhodopsin Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 200-301-E29
- Zusätzliche Namen:
- OPN2, Rhodopsin, RHO, Anti-Rhodopsin monoclonal, photoreceptor proteins|RHO
- Anwendung:
- IHC, WB
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Bovine
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Host:
- Mouse
- Buffer:
- 0.01 M HEPES, 0.15 M Sodium Chloride
- Immunogen:
- Anti-Rhodopsin Monoclonal Antibody was produced in mouse by repeated immunizations with purified native bovine rhodopsin.
- Formulierung:
- 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
- Klon:
- 1D4
- Uniprot:
- P02699
- Synonyme:
- rhodopsin;rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)
- Weitere Details:
- Rhodopsin antibody detects rhodopsin which is a photoreceptor protein found in retinal rods. It is a complex formed by the binding of retinaldehyde, the oxidized form of retinol, to the protein opsin and undergoes a series of complex reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis. Other mutations on rhodopsin lead to X-linked congenital stationary night blindness, mainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin. Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding. Anti-Rhodopsin Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
- Versandbedingungen:
- Dry Ice