Mesothelin Antibody

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SKU:: 200-301-A88S
Zusätzliche Namen:: mouse anti-Mesothelin Antibody, Mesothelian, MN, MB, Pre-pro-megakaryocyte-potentiating factor, CAK1 antigen|MSLN
Anwendung:: ELISA, Flow Cytometry, IHC, WB, IP
Konzentration:: 1 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C diluted. Avoid freeze/thaw cycles., See Manual Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Mouse
Reaktivitäten:: Human
Buffer:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
Immunogen:: This antibody was produced in mesothelin-deficient mice by immunizations with plasmid cDNA encoding human MSLN full length protein followed by a single boost of a recombinant human mesothelin-Fc fusion protein.
Formulierung:: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Klon:: MN-1
Uniprot:: Q13421
Synonyme:: CAK1 antigen;megakaryocyte potentiating factor;mesothelin;MPF;pre-pro-megakaryocyte-potentiating factor;SMRP;soluble MPF mesothelin related protein
Weitere Details:: Mesothelin is a glycosyl-phosphatidyl-inositol-anchored glycoprotein present on the cell surface of various human solid tumors. The mesothelin (MSLN) gene encodes a 71-kDa precursor protein that is processed to a 40-kDa glycosylphosphatidyl-inositol-anchored protein that composes the mature portion and an NH2-terminal 31-kDa fragment called megakaryocyte-potentiating factor that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues, such as mesothelium, but aberrantly over expressed in mesotheliomas, ovarian, and pancreatic cancers. The biological functions of mesothelin remain elusive. A recent study showed that mesothelin binds to MUC16/CA125, and that this interaction mediates cell adhesion, suggesting that there may be an important role for MUC16/CA125 and mesothelin in the metastatic spread of ovarian cancer.

Versandbedingungen:: Dry Ice