200-301-279
LEFTY A Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 200-301-279
- Zusätzliche Namen:
- LEFTY2|mouse anti-leftyA antibody, mouse anti-protein lefty 2 antibody, Left-right determination factor 2 antibody, Protein lefty-2 antibody, Left-right determination factor A antibody, Protein lefty-A antibody, Transforming growth factor beta-4 antibody, TGF-beta-4 antibody, Endometrial bleeding-associated factor antibody
- Anwendung:
- ELISA, WB
- Konzentration:
- 1.051 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- A BALB/c mouse was immunized with a recombinant form of 6X HIS tagged human LEFTY.
- Formulierung:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Klon:
- 7C5G1H6H10
- Uniprot:
- O00292
- Synonyme:
- EBAF;endometrial bleeding-associated factor;left-right determination factor 2;left-right determination factor A;LEFTA;LEFTYA;protein lefty-2;protein lefty-A;TGF-beta-4;TGFB4;transforming growth factor beta-4
- Weitere Details:
- During vertebrate embryogenesis, a left-right axis is established. Secreted growth factors of the TGF-beta family, including gene products derived from nodal, lefty-1 and lefty-2, play crucial roles in establishing left-right asymmetries. TGF-beta (Transforming growth factor-beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF-beta actions are directed by ligand-induced activation of TGF-beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF-beta superfamily, inhibits TGF-beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF-beta receptor. Lefty also inhibits events downstream from R-Smad phosphorylation. Lefty provides a repressed state of TGF-beta-responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF-beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (42 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28kDa form induces MAPK activity.
- Versandbedingungen:
- Dry Ice