100-401-V08
ETO Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 100-401-V08
- Zusätzliche Namen:
- Protein CBFA2T1, Cyclin-D-related protein, Eight twenty one protein, Protein ETO, Protein MTG8, Zinc finger MYND domain-containing protein 2, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMTND2|RUNX1T1
- Anwendung:
- ChIP, ELISA
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Immunogen:
- Anti-ETO Antibody was produced in rabbits by repeated immunizations with human ETO using two synthetic peptides containing sequences from the N-terminal and internal region of the protein respectively.
- Format:
- Antiserum
- Uniprot:
- Q06455
- Synonyme:
- acute myelogenous leukemia 1 translocation 1, cyclin-D related;AML1-MTG8;AML1T1;CBFA2T1;CDR;core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related;Cyclin-D-related protein;eight twenty one protein;ETO;MTG8;myeloid translocation gene on 8q22;protein CBFA2T1;Protein ETO;Protein MTG8;runt related transcription factor 1; translocated to, 1 (cyclin D related);RUNX1 translocation partner 1;zinc finger MYND domain-containing protein 2;ZMYND2
- Weitere Details:
- ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5'-region of AML1 and the 3'-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Anti-ETO Antibody is ideal for research in Gene Expression, Transcription and Cancer.
- Versandbedingungen:
- Dry Ice