100-401-J04S
Eg5 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 100-401-J04S
- Zusätzliche Namen:
- KIF11|rabbit anti-Eg5 antibody, Kinesin-like protein KIF11, Kinesin-5, KIF11, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5
- Anwendung:
- ELISA, IHC, WB
- Konzentration:
- 46 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C diluted. Avoid freeze/thaw cycles., See Manual Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- Eg5 was prepared from whole rabbit serum produced by repeated immunizations with a truncated Eg5 construct expressed in E. coli corresponding to human Eg5 protein.
- Formulierung:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Format:
- Antiserum
- Uniprot:
- P52732
- Synonyme:
- conventional kinesin heavy chain;EG5;epididymis secretory protein Li 61;HEL-S-61;HKSP;kinesin 1 (110-120kD);kinesin heavy chain;kinesin-1 heavy chain;kinesin-like protein 1;kinesin-like protein KIF11;kinesin-like spindle protein HKSP;kinesin-related motor protein Eg5;KINH;KNS;KNS1;KNSL1;MCLMR;thyroid receptor-interacting protein 5;TR-interacting protein 5;TRIP-5;TRIP5;ubiquitous kinesin heavy chain;UKHC
- Weitere Details:
- Eg5 (also known as kinesin-5 and KIF11) is a homo-tetramer which cross-links anti-parallel microtubules in the mitotic spindle to maintain spindle bipolarity. Eg5, a member of the Kinesin-5 subclass of kinesins, is a plus-end-directed tetrameric kinesin-family protein that influences the assembly and organization of the mitotic spindle, a self-assembled and dynamic microtubule-based structure that orchestrates chromosome segregation in dividing cells. Eg5 action is essential: when it is depleted from the cytoplasm of meiotically-mature Xenopus laevis eggs, abnormal monopolar spindles form, preventing successful division. Eg5 is expressed in all cells during mitosis and in post-mitotic neurons during development. In developing neurons pharmacological inhibition and siRNA knockdown of Eg5 results in longer axons, more branches, fewer bouts of axon retraction and the inability of growth cones to turn on contact with repulsive substrates. In migratory neurons, inhibition of Eg5 causes neurons to migrate in a random pattern and form shorter leading processes. In adult neurons, Eg5 has a similar effect on inhibiting the rate of short microtubule transport so pharmacological inhibition of adult Eg5 (i.e Monastrol) may be a potential therapeutic tool for the augmentation of adult axon regeneration.
- Versandbedingungen:
- Dry Ice