100-401-B63
Scythe/Bat3 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 100-401-B63
- Zusätzliche Namen:
- Bag6|rabbit anti-Bat3 Antibody, rabbit anti-Scythe Antibody, Human Leukocyte Antigen-B-Associated Transcript 3, HLA-B-associated transcript 3, BAT3, Large proline-rich protein BAT3, Large proline-rich protein BAG6, BAG family molecular chaperone regulator 6, BCL2-associated athanogene 6, HLA-B-associated transcript 3
- Anwendung:
- ELISA, WB
- Konzentration:
- 80 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Mouse
- Lagerbedingungen:
- -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride
- Immunogen:
- This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminal portion of mouse Scythe/BAT3.
- Formulierung:
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Format:
- Antiserum
- Uniprot:
- Q9Z1R2
- Synonyme:
- 2410045D21Rik;AA408914;BAG family molecular chaperone regulator 6;BAG-6;Bat;Bat3;BCL2-associated athanogene 6;D17H6S52;D17H6S52E;G3;HLA-B-associated transcript 3;large proline-rich protein BAG6;large proline-rich protein BAT3;protein Scythe;Scyth;Scythe
- Weitere Details:
- Scythe protein (also known as BAT3 and HLA-B-associated transcript 3) is an apoptotic regulator that is highly conserved in eukaryotes and contains a ubiquitin-like domain near its N-terminus. It binds Reaper, a potent apoptotic inducer, as well as Hid and Grim. Scythe and Reaper are thought to signal apoptosis, in part through regulating the folding and activity of apoptotic signaling molecules. Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis. It interacts with transforming growth factor-beta (TGF-beta) receptors and enhances TGF-beta1-induced type I collagen expression in mesangial cells. With SET1A, Scythe forms a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. Scythe is essential for p300-mediated acetylation of p53. Scythe/BAT3 is identified as a critical regulator of Hsp70-2 in spermatogenesis, thereby providing a possible molecular target in idiopathic male infertility. The human Scythe/BAT3 ortholog in rodents is predominantly and developmentally expressed in testis.
- Versandbedingungen:
- Dry Ice