ROC2 Antibody

Eine Lieferung in diese Region ist nicht möglich.

SKU:: 100-401-A14
Zusätzliche Namen:: rabbit anti-ROC2 antibody, GTP binding protein Roc2 antibody, Ras like protein expressed in neurons antibody, Ras like without CAAX 2 antibody, Ras like without CAAX protein 2 antibody, RIBA antibody, Ric (Drosophila) like antibody, Ric like antibody, RIN antibody|RNF7
Anwendung:: ELISA, IHC, WB, IP
Konzentration:: 85 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C aliquoted. Aliquot. Avoid freeze/thaw cycles., 2-8[o]C diluted. Aliquot. Avoid freeze/thaw cycles.
Hersteller:: Rockland Inc
Host:: Rabbit
Reaktivitäten:: Human
Immunogen:: This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 102-113 of Human ROC2 (C-terminal) coupled to KLH.
Format:: Antiserum
Uniprot:: Q9UBF6
Synonyme:: CKBBP1;CKII beta-binding protein 1;rbx2;regulator of cullins 2;RING finger protein 7;RING-box protein 2;ROC2;SAG;sensitive to apoptosis gene protein;sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2;zinc RING finger protein SAG
Weitere Details:: ROC2 also known as RING-box protein 2, Rbx2, RING finger protein 7, Regulator of cullins 2, CKII beta-binding protein 1, and CKBBP1, is a probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC2 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. ROC2 may play a role in protecting cells from apoptosis induced by redox agents. ROC2 has a cytoplasmic and nuclear localization and is expressed in heart, liver, skeletal muscle and pancreas tissues, and at very low levels in brain, placenta and lung. 1,10-phenanthroline induces ROC2 expression. The RING-type zinc finger domain is essential for ubiquitin ligase activity. Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.

Versandbedingungen:: Dry Ice