100-401-A03
Cul3 Antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 100-401-A03
- Zusätzliche Namen:
- CUL3|rabbit anti-Cul3 Antibody, rabbit anti-Cullin3 antibody, KIAA0617 antibody, CUL, Cullin
- Anwendung:
- ELISA, IHC, WB, IP
- Konzentration:
- 85 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Rockland Inc
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Immunogen:
- Cul3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the N-Terminal near amino acids 1-25 of Human Cul3 coupled to KLH.
- Format:
- Antiserum
- Uniprot:
- Q13618
- Synonyme:
- CUL-3;cullin-3;NEDAUS;PHA2E
- Weitere Details:
- Cul3 antibody is ideal for Cell Biology, Cancer and Ubiquitin research. Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 3 is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul3 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul3 may also contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Unlike Cul1 and Cul2, Cul3 seems not to be a part of the SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Cul3 also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.
- Versandbedingungen:
- Dry Ice