009-001-E71
AKT2 (phosphatase treated) Human Recombinant Protein
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- 009-001-E71
- Zusätzliche Namen:
- AKT2|RAC, PKB, AKT,PKB beta
- Anwendung:
- SDS-PAGE, WB
- Konzentration:
- 1.17 mg/ml
- Physischer Zustand:
- Liquid
- Reinheit:
- >90%
- Lagerbedingungen:
- Please refer to datasheet
- Hersteller:
- Rockland Inc
- Buffer:
- 20 mM Tris pH8, 300 mM NaCl with 10% glycerol
- Immunogen:
- AKT2
- Formulierung:
- 20 mM Tris pH8, 300 mM NaCl with 10% glycerol
- Spezies:
- Human
- Uniprot:
- P31751
- Synonyme:
- HIHGHH;murine thymoma viral (v-akt) homolog-2;PKB beta;PKBB;PKBBETA;PRKBB;protein kinase Akt-2;protein kinase B beta;putative v-akt murine thymoma viral oncoprotein 2;rac protein kinase beta;RAC-BETA;RAC-beta serine/threonine-protein kinase;RAC-PK-beta;v-akt murine thymoma viral oncogene homolog 2
- Weitere Details:
- AKT2 is a component of the PI-3 kinase pathway and is activated by phosphorylation at Ser 473 and Thr 308. AKT is a cytoplasmic protein also known as Protein Kinase B (PKB) and RAC (Related to A and C kinases). AKT is a key regulator of many signal transduction pathways, and it exhibits tight control over cell proliferation and cell viability. Overexpression or inappropriate activation of AKT is noted in many types of cancer. AKT mediates many of the downstream events of PI 3-kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3-kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. AKT2 recombinant protein is ideal for investigators involved in Cell Signaling, Neuroscience and Signal Transduction research.
- Versandbedingungen:
- Dry Ice