GTX89815
RNF34 antibody, N-term
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX89815
- Zusätzliche Namen:
- ring finger protein 34 , CARP-1 , CARP1 , RFI , RIF , RIFF , hRFI
- Anwendung:
- IHC-P
- Konzentration:
- 0.50 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Ammonium Sulfate Precipitated; Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence KAGATSMWASCC, from the N Terminus of the protein sequence according to NP_919247.1; NP_079402.2.
- Uniprot:
- Q969K3
- Synonyme:
- CARP-1;CARP1;caspase regulator CARP1;caspases-8 and -10-associated RING finger protein 1;E3 ubiquitin-protein ligase RNF34;FYVE-RING finger protein MOMO;hRFI;human RING finger homologous to inhibitor of apoptosis protein;RFI;RIF;RIFF;RING finger protein 34;ring finger protein 34, E3 ubiquitin protein ligase;RING finger protein RIFF;RING-type E3 ubiquitin transferase RNF34
- Weitere Details:
- The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
- Versandbedingungen:
- Blue Ice