GTX89687-PEP
PPAR delta (Isoform 1) blocking peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX89687-PEP
- Zusätzliche Namen:
- Peroxisome Proliferator Activated Receptor Delta , Faar , Nr1C2 , Nuc1 , Nuci , Nucii , Pparb , Ppard
- Physischer Zustand:
- Lyophilized
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- peroxisome proliferator activated receptor delta
- Spezies:
- Human
- Synonyme:
- FAAR;NR1C2;NUC1;NUCI;NUCII;nuclear hormone receptor 1;nuclear receptor subfamily 1 group C member 2;peroxisome proliferator-activated receptor beta;peroxisome proliferator-activated receptor delta;PPAR-beta;PPAR-delta;PPARB;PPARD/MYO1D fusion
- Weitere Details:
- This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
- Versandbedingungen:
- Blue Ice