GTX89320
SH2D1A antibody, Internal
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX89320
- Zusätzliche Namen:
- SH2 domain containing 1A , DSHP , EBVS , IMD5 , LYP , MTCP1 , SAP , SAP/SH2D1A , XLP , XLPD , XLPD1
- Anwendung:
- WB, IP
- Konzentration:
- 0.50 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Ammonium Sulfate Precipitated; Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence C-QYPVEKKSSARSTQ, from the internal region of the protein sequence according to NP_002342.1; NP_001108409.1.
- Uniprot:
- O60880
- Synonyme:
- DSHP;Duncan disease SH2-protein;EBVS;IMD5;LYP;MTCP1;SAP;SAP/SH2D1A;SH2 domain-containing protein 1A;signaling lymphocyte activation molecule-associated protein;signaling lymphocytic activation molecule-associated protein;SLAM associated protein/SH2 domain protein 1A;SLAM-associated protein;T cell signal transduction molecule SAP;T-cell signal transduction molecule SAP;XLP;XLPD;XLPD1
- Weitere Details:
- This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice