NCF4 antibody, Internal

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX89030
Zusätzliche Namen:: neutrophil cytosolic factor 4 , CGD3 , NCF , P40PHOX , SH3PXD4
Anwendung:: WB, IHC-P
Konzentration:: 0.50 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Ammonium Sulfate Precipitated; Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Goat
Reaktivitäten:: Human
Buffer:: TBS, 0.5% BSA, 0.02% Sodium azide.
Immunogen:: Peptide with sequence C-KDFPEEDDPTN, from the internal region of the protein sequence according to NP_000622.2; NP_038202.1.
Uniprot:: Q15080
Synonyme:: CGD3;NCF;NCF-4;neutrophil cytosol factor 4;neutrophil cytosolic factor 4, 40kDa;neutrophil NADPH oxidase factor 4;p40-phox;P40PHOX;SH3 and PX domain-containing protein 4;SH3PXD4
Weitere Details:: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Versandbedingungen:: Blue Ice