GTX88886-PEP
Factor XIIIa (703-717) blocking peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX88886-PEP
- Zusätzliche Namen:
- Coagulation Factor Xiii A Chain , F13A , F13A1
- Physischer Zustand:
- Lyophilized
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- coagulation factor XIII A chain
- Spezies:
- Human
- Synonyme:
- bA525O21.1 (coagulation factor XIII, A1 polypeptide);coagulation factor XIII A chain;coagulation factor XIII, A polypeptide;coagulation factor XIII, A1 polypeptide;coagulation factor XIIIa;F13A;factor XIIIa;fibrin stabilizing factor, A subunit;fibrinoligase;FSF, A subunit;protein-glutamine gamma-glutamyltransferase A chain;TGase;transglutaminase A chain;transglutaminase. plasma
- Weitere Details:
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice