ERCC1 antibody, N-term

Eine Lieferung in diese Region ist nicht möglich.

SKU:: GTX88627
Zusätzliche Namen:: ERCC excision repair 1, endonuclease non-catalytic subunit , COFS4 , RAD10 , UV20
Anwendung:: WB
Konzentration:: 0.50 mg/ml
Physischer Zustand:: Liquid
Spezies-Reaktivität:: Human
Aufreinigung:: Ammonium Sulfate Precipitated; Affinity Purified
Lagerbedingungen:: -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
Hersteller:: Genetex
Host:: Goat
Reaktivitäten:: Human
Buffer:: TBS, 0.5% BSA, 0.02% Sodium azide.
Immunogen:: Peptide with sequence DPGKDKEGVPQPS-C, from the N Terminus of the protein sequence according to NP_973730.1; NP_001974.1.
Uniprot:: P07992
Synonyme:: COFS4;DNA excision repair protein ERCC-1;excision repair cross-complementation group 1;excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence);RAD10;UV20
Weitere Details:: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Versandbedingungen:: Blue Ice