GTX88474
PXR antibody, Internal
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX88474
- Zusätzliche Namen:
- nuclear receptor subfamily 1 group I member 2 , BXR , ONR1 , PAR , PAR1 , PAR2 , PARq , PRR , PXR , SAR , SXR
- Anwendung:
- WB, IHC-P
- Konzentration:
- 0.50 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Ammonium Sulfate Precipitated; Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Goat
- Reaktivitäten:
- Human
- Buffer:
- TBS, 0.5% BSA, 0.02% Sodium azide.
- Immunogen:
- Peptide with sequence EQFAITLKSYIECNR, from the internal region of the protein sequence according to NP_003880.3; NP_071285.1; NP_148934.1.
- Uniprot:
- O75469
- Synonyme:
- BXR;nuclear receptor subfamily 1 group I member 2;ONR1;orphan nuclear receptor PAR1;orphan nuclear receptor PXR;PAR;PAR1;PAR2;PARq;pregnane X nuclear receptor variant 2;pregnane X receptor;PRR;PXR;SAR;steroid and xenobiotic receptor;SXR
- Weitere Details:
- This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
- Versandbedingungen:
- Blue Ice