GTX88456-PEP
HMGCR blocking peptide
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX88456-PEP
- Zusätzliche Namen:
- 3-Hydroxy-3-Methylglutaryl-Coa Reductase , Ldlcq3 , Hmgcr
- Physischer Zustand:
- Lyophilized
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Buffer:
- Reconstitute with 200ul distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O, no preservatives.
- Immunogen:
- 3-hydroxy-3-methylglutaryl-CoA reductase
- Spezies:
- Human
- Synonyme:
- 3-hydroxy-3-methylglutaryl CoA reductase (NADPH);3-hydroxy-3-methylglutaryl-Coenzyme A reductase;HMG-CoA reductase;hydroxymethylglutaryl-CoA reductase;LDLCQ3
- Weitere Details:
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
- Versandbedingungen:
- Blue Ice