GTX85522
SKI antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85522
- Zusätzliche Namen:
- SKI proto-oncogene , SGS , SKV
- Anwendung:
- ELISA, WB, IHC-P
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Ski antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Ski.The immunogen is located within the first 50 amino acids of Ski.
- Uniprot:
- P12755
- Synonyme:
- proto-oncogene c-Ski;SGS;ski oncogene;ski oncoprotein;SKV;v-ski avian sarcoma viral oncogene homolog
- Weitere Details:
- TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
- Versandbedingungen:
- Blue Ice