GTX85517
MD2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85517
- Zusätzliche Namen:
- lymphocyte antigen 96 , ESOP-1 , MD-2 , MD2 , ly-96
- Anwendung:
- ELISA, WB, IHC-P, IHC-Fr
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- MD-2 antibody was raised against a peptide corresponding to 13 amino acids near the center of human MD-2.The immunogen is located within the last 50 amino acids of MD-2.
- Uniprot:
- Q9Y6Y9
- Synonyme:
- ESOP-1;ly-96;lymphocyte antigen 96;MD-2;MD2;myeloid differentiation protein-2;protein MD-2
- Weitere Details:
- MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).
- Versandbedingungen:
- Blue Ice