GTX85492
TIP47 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85492
- Zusätzliche Namen:
- perilipin 3 , M6PRBP1 , PP17 , TIP47
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- TIP47 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TIP47. The immunogen is located within aa 385-434 of human TIP47 (UniProt #O60664).
- Uniprot:
- O60664
- Synonyme:
- 47 kDa mannose 6-phosphate receptor-binding protein;47 kDa MPR-binding protein;cargo selection protein TIP47;M6PRBP1;mannose-6-phosphate receptor-binding protein 1;perilipin-3;placental protein 17;PP17;tail-interacting protein, 47 kD;testicular tissue protein Li 114;TIP47
- Weitere Details:
- Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.
- Versandbedingungen:
- Blue Ice