GTX85449
PD-L2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85449
- Zusätzliche Namen:
- programmed cell death 1 ligand 2 , B7DC , Btdc , CD273 , PD-L2 , PDCD1L2 , PDL2 , bA574F11.2
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- PD-L2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human PD-L2.The immunogen is located within amino acids 140 - 190 of PD-L2.
- Uniprot:
- Q9BQ51
- Synonyme:
- B7 dendritic cell molecule;B7-DC;B7DC;bA574F11.2;Btdc;butyrophilin B7-DC;CD273;PD-1-ligand 2;PD-L2;PDCD1 ligand 2;PDCD1L2;PDL2;programmed cell death 1 ligand 2;programmed death ligand 2
- Weitere Details:
- Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist; this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.
- Versandbedingungen:
- Blue Ice