GTX85439
CRLF2 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85439
- Zusätzliche Namen:
- cytokine receptor-like factor 2 , CRLM2 , Ly114 , Tpte2 , Tslpr
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CRLF2 antibody was raised against a 21 amino acid synthetic peptide from near the center of mouse CRLF2.The immunogen is located within amino acids 140 - 190 of CRLF2.
- Uniprot:
- Q8CII9
- Synonyme:
- CRLM2;cytokine receptor-like factor 2;cytokine receptor-like molecule 2;Ly11;Ly114;lymphocyte antigen 114;T;thymic stromal lymphopoietin protein receptor;thymic stromal-derived lymphopoietin, receptor;Tpte;Tpte2;transmembrane phosphoinositide 3-phosphatase and tensin homolog 2;TSLP receptor;Tslpr;type I cytokine receptor delta 1
- Weitere Details:
- Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1. The approximately 75kDa band seen in the immunoblot may be a post-translationally modified form of TSLP-R.
- Versandbedingungen:
- Blue Ice