GTX85433
CCDC98 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85433
- Zusätzliche Namen:
- abraxas 1, BRCA1 A complex subunit , ABRA1 , CCDC98 , FAM175A
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CCDC98 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98.The immunogen is located within amino acids 80 - 130 of CCDC98.
- Uniprot:
- Q6UWZ7
- Synonyme:
- ABRA1;abraxas protein;BRCA1-A complex subunit Abraxas 1;CCDC98;coiled-coil domain containing 98;Coiled-coil domain-containing protein 98;FAM175A;family with sequence similarity 175 member A;Protein FAM175A
- Weitere Details:
- CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
- Versandbedingungen:
- Blue Ice