GTX85432
CDNF antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85432
- Zusätzliche Namen:
- cerebral dopamine neurotrophic factor , ARMETL1
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- CDNF antibody was raised against a 9 amino acid synthetic peptide from near the carboxy terminus of human CDNF.The immunogen is located within the last 50 amino acids of CDNF.
- Uniprot:
- Q49AH0
- Synonyme:
- arginine-rich, mutated in early stage tumors-like 1;ARMET-like protein 1;ARMETL1;cerebral dopamine neurotrophic factor;conserved dopamine neurotrophic factor
- Weitere Details:
- The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist. This antibody does not cross-react with MANF.
- Versandbedingungen:
- Blue Ice