GTX85426
TEM4 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85426
- Zusätzliche Namen:
- Rho guanine nucleotide exchange factor 17 , P164RHOGEF , RHOGEF17 , TEM4 , p164-RhoGEF
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- TEM4 antibody was raised against a 18 amino acid synthetic peptide near the center of human TEM4.The immunogen is located within amino acids 910 - 960 of TEM4.
- Uniprot:
- Q96PE2
- Synonyme:
- 164 kDa Rho-specific guanine-nucleotide exchange factor;p164-RhoGEF;P164RHOGEF;Rho guanine nucleotide exchange factor (GEF) 17;rho guanine nucleotide exchange factor 17;Rho-specific guanine-nucleotide exchange factor 164 kDa;RHOGEF17;TEM4;tumor endothelial marker 4
- Weitere Details:
- Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
- Versandbedingungen:
- Blue Ice