GTX85400
COPS8 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85400
- Zusätzliche Namen:
- COP9 signalosome subunit 8 , COP9 , CSN8 , SGN8
- Anwendung:
- ELISA, WB
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- COPS8 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human COPS8.The immunogen is located within the last 50 amino acids of COPS8.
- Uniprot:
- Q99627
- Synonyme:
- COP9;COP9 constitutive photomorphogenic homolog subunit 8;COP9 homolog;COP9 signalosome complex subunit 8;CSN8;hCOP9;JAB1-containing signalosome subunit 8;SGN8;signalosome subunit 8
- Weitere Details:
- The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
- Versandbedingungen:
- Blue Ice