GTX85399
Slc35D1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85399
- Zusätzliche Namen:
- solute carrier family 35 member D1 , SHNKND , UGTREL7
- Anwendung:
- ELISA, WB, IF, ICC
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Slc35D1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human Slc35D1.The immunogen is located within the last 50 amino acids of Slc35D1.
- Uniprot:
- Q9NTN3
- Synonyme:
- SHNKND;solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1;solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1;Solute carrier family 35 member D1;UDP-galactose transporter-related 7;UDP-galactose transporter-related protein 7;UDP-GlcA/UDP-GalNAc transporter;UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter;UGTREL7
- Weitere Details:
- The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia. This antibody is predicted to not cross-react with the highly homologous Slc35D2.
- Versandbedingungen:
- Blue Ice