GTX85386
TRIM30 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85386
- Zusätzliche Namen:
- tripartite motif-containing 30A , Rpt-1 , Rpt1 , Trim30
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human, Mouse
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- TRIM30 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of the mouse TRIM30.The immunogen is located within amino acids 250 - 300 of TRIM30.
- Uniprot:
- P15533
- Synonyme:
- down regulatory protein of interleukin-2 receptor;regulatory protein, T lymphocyte 1;Rp;Rpt;Rpt-1;Rpt1;Trim;Trim30;tripartite motif protein 30;tripartite motif-containing 30;tripartite motif-containing protein 30;tripartite motif-containing protein 30A
- Weitere Details:
- TRIM30 belongs to a family of the tripartite motif (TRIM) proteins involved in the regulation of cell proliferation, differentiation, development, oncogenesis, apoptosis and antiviral responses. The TRIM protein family is an expanding family of RING ('really interesting new gene') proteins, also known as RBCC proteins as they contain an RBCC motif, which comprises a RING domain, one or two B-boxes and a predicted coiled-coil region. Studies have shown that some TRIM family members are critical to innate immunity; TRIM5, TRIM19 and TRIM25, for example, have been shown to restrict viral infection. A recent study shows that TRIM30 functions as a negative modulator of the TLR signaling pathway, by targeting TAB2 and TAB3, and contributes to the inhibition of TLR-mediated NFkappa-B activation. The importance of TRIM30 in the attenuation or termination of NFkappa-B activation suggests that targeting of TAB2 and TAB3 by TRIM30 alpha may be a mechanism for modulating many types of immune responses.
- Versandbedingungen:
- Blue Ice