GTX85376
Spred1 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85376
- Zusätzliche Namen:
- sprouty related EVH1 domain containing 1 , NFLS , PPP1R147 , hSpred1 , spred-1
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- Spred1 antibody was raised against a 14 amino acid synthetic peptide near the center of the human Spred1.The immunogen is located within amino acids 250 - 300 of Spred1.
- Uniprot:
- Q7Z699
- Synonyme:
- hSpred1;LGSS;NFLS;PPP1R147;protein phosphatase 1, regulatory subunit 147;spred-1;sprouty-related, EVH1 domain-containing protein 1;suppressor of Ras/MAPK activation
- Weitere Details:
- The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.
- Versandbedingungen:
- Blue Ice