GTX85358
TOM70 antibody
Eine Lieferung in diese Region ist nicht möglich.
- SKU:
- GTX85358
- Zusätzliche Namen:
- translocase of outer mitochondrial membrane 70 , TOMM70A , Tom70
- Anwendung:
- ELISA, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Physischer Zustand:
- Liquid
- Spezies-Reaktivität:
- Human
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., 2-8[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted., -20[o]C/-70[o]C Aliquot. Avoid freeze/thaw cycles. Store undiluted.
- Hersteller:
- Genetex
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 0.02% Sodium azide.
- Immunogen:
- TOM70 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TOM70.The immunogen is located within amino acids 50 - 100 of TOM70.
- Uniprot:
- O94826
- Synonyme:
- mitochondrial import receptor subunit TOM70;mitochondrial precursor proteins import receptor;Tom70;TOMM70A;translocase of outer membrane 70 kDa subunit;translocase of outer mitochondrial membrane 70 homolog A;translocase of outer mitochondrial membrane protein 70
- Weitere Details:
- The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.
- Versandbedingungen:
- Blue Ice